RNA Aptamer Evolution: Two Decades of SELEction

Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 19...

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Main Authors:	Guillermo Aquino-Jarquin, Julia D. Toscano-Garibay
Format:	Article
Language:	English
Published:	MDPI AG 2011-12-01
Series:	International Journal of Molecular Sciences
Subjects:	non-coding RNAs aptamers SELEX in vitro selection in vitro evolution
Online Access:	http://www.mdpi.com/1422-0067/12/12/9155/

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spelling	doaj-f48d913ae8234a57bbc56b05599cb9ae2020-11-25T00:48:55ZengMDPI AGInternational Journal of Molecular Sciences1422-00672011-12-0112129155917110.3390/ijms12129155RNA Aptamer Evolution: Two Decades of SELEctionGuillermo Aquino-JarquinJulia D. Toscano-GaribayAptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the recognition of targets, starting with small molecules, going through protein complexes until whole cells. SELEX has also evolved along with new technologies positioning itself as an alternative in the design of a new class of therapeutic agents in modern molecular medicine. This review is an historical follow-up of SELEX method over the two decades since its first appearance.http://www.mdpi.com/1422-0067/12/12/9155/non-coding RNAsaptamersSELEXin vitro selectionin vitro evolution
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Guillermo Aquino-Jarquin Julia D. Toscano-Garibay
spellingShingle	Guillermo Aquino-Jarquin Julia D. Toscano-Garibay RNA Aptamer Evolution: Two Decades of SELEction International Journal of Molecular Sciences non-coding RNAs aptamers SELEX in vitro selection in vitro evolution
author_facet	Guillermo Aquino-Jarquin Julia D. Toscano-Garibay
author_sort	Guillermo Aquino-Jarquin
title	RNA Aptamer Evolution: Two Decades of SELEction
title_short	RNA Aptamer Evolution: Two Decades of SELEction
title_full	RNA Aptamer Evolution: Two Decades of SELEction
title_fullStr	RNA Aptamer Evolution: Two Decades of SELEction
title_full_unstemmed	RNA Aptamer Evolution: Two Decades of SELEction
title_sort	rna aptamer evolution: two decades of selection
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2011-12-01
description	Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the recognition of targets, starting with small molecules, going through protein complexes until whole cells. SELEX has also evolved along with new technologies positioning itself as an alternative in the design of a new class of therapeutic agents in modern molecular medicine. This review is an historical follow-up of SELEX method over the two decades since its first appearance.
topic	non-coding RNAs aptamers SELEX in vitro selection in vitro evolution
url	http://www.mdpi.com/1422-0067/12/12/9155/
work_keys_str_mv	AT guillermoaquinojarquin rnaaptamerevolutiontwodecadesofselection AT juliadtoscanogaribay rnaaptamerevolutiontwodecadesofselection
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RNA Aptamer Evolution: Two Decades of SELEction

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