High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.

High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.

Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in patients with dysmetabolic overload syndrome (DIOS). Genetic factors and Western diet represent predisposing conditions, but the mechanisms...

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Main Authors: Paola Dongiovanni, Claudia Lanti, Stefano Gatti, Raffaela Rametta, Stefania Recalcati, Marco Maggioni, Anna Ludovica Fracanzani, Patrizia Riso, Gaetano Cairo, Silvia Fargion, Luca Valenti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4315491?pdf=render

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