Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth

Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth

Cyclophosphamide (CTX) is widely used in various cancer therapies and in immunosuppression, and patients can still have babies after CTX chemotherapy. CTX directly causes primordial follicle loss with overactivation and DNA damage-induced apoptosis. Previous studies have shown that maternal exposure...

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Bibliographic Details
Main Authors: Weijie Yang, Yerong Ma, Jiamin Jin, Peipei Ren, Hanjing Zhou, Shiqian Xu, Yingyi Zhang, Zhanhong Hu, Yan Rong, Yongdong Dai, Yinli Zhang, Songying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cyclophosphamide
maternal factor
histone modification
methylation
primordial follicle
oocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.682060/full

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