Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

In analyzing the sequence tags for mutant mouse embryonic stem (ES) cell lines in BayGenomics (a mouse gene-trapping resource), we identified a novel gene, 1-acylglycerol-3-phosphate O-acyltransferase (Agpat6), with sequence similarities to previously characterized glycerolipid acyltransferases. Agp...

Full description

Bibliographic Details
Main Authors:	Anne P. Beigneux, Laurent Vergnes, Xin Qiao, Steven Quatela, Ryan Davis, Steven M. Watkins, Rosalind A. Coleman, Rosemary L. Walzem, Mark Philips, Karen Reue, Stephen G. Young
Format:	Article
Language:	English
Published:	Elsevier 2006-04-01
Series:	Journal of Lipid Research
Subjects:	acyltransferase transacylase milk fat
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520332697

Similar Items

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
by: Laurent Vergnes, et al.
Published: (2006-04-01)

Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria[S]
by: Sneha S. Prasad, et al.
Published: (2011-03-01)

Growth and acyltransferase activity of rabbit mammary gland during pregnancy and lactation
by: M Caffrey, et al.
Published: (1977-01-01)

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice
by: Cynthia A. Nagle, et al.
Published: (2008-04-01)

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2−/− lipodystrophic mice independent of hepatocyte leptin receptors[S]
by: Víctor A. Cortés, et al.
Published: (2014-02-01)

Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells
by: J. Matías Caviglia, et al.
Published: (2004-08-01)

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice
by: Anil K. Agarwal, et al.
Published: (2016-04-01)

Identification of Acyltransferases Associated with Triacylglycerol Biosynthesis in Avocado
by: Sung, Ha-Jung
Published: (2013)

The Structure and Function of Acylglycerophosphate Acyltransferase 4/ Lysophosphatidic Acid Acyltransferase Delta (AGPAT4/LPAATδ)
by: Mikhail A. Zhukovsky, et al.
Published: (2019-08-01)

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism
by: Chi-Liang Eric Yen, et al.
Published: (2015-03-01)

GENOMIQUE ET PRODUCTION NON ALIMENTAIRE Acides gras d’intérêt industriel obtenus par génie génétique
by: Lessire René
Published: (2002-03-01)

Identification of Acyltransferases Associated with Triacylglycerol Biosynthesis in Avocado Fruit
by: Sung, Ha-Jung, et al.
Published: (2012)

Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph
by: LaTonya Washington, et al.
Published: (2003-07-01)

Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes
by: David L. Lankester, et al.
Published: (1998-09-01)

Increased triacylglycerol production in oleaginous microalga Neochloris oleoabundans by overexpression of plastidial lysophosphatidic acid acyltransferase
by: Wipa Chungjatupornchai, et al.
Published: (2019-03-01)

Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots
by: Emily B. Mardian, et al.
Published: (2017-10-01)

Effect of 50 Hz electric field in diacylglycerol acyltransferase mRNA expression level and plasma concentration of triacylglycerol, free fatty acid, phospholipid and total cholesterol
by: Hori Takuya, et al.
Published: (2012-06-01)

In vivo reconstitution of algal triacylglycerol production in Saccharomyces cerevisiae
by: Chun-Hsien eHung, et al.
Published: (2016-02-01)

The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids
by: Yang Zhao, et al.
Published: (2009-05-01)

Characterization of type-2 diacylglycerol acyltransferases in Haematococcus lacustris reveals their functions and engineering potential in triacylglycerol biosynthesis
by: Hongli Cui, et al.
Published: (2021-01-01)

Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
by: Chi-Liang Eric Yen, et al.
Published: (2008-11-01)

Accelerated triacylglycerol production and altered fatty acid composition in oleaginous microalga Neochloris oleoabundans by overexpression of diacylglycerol acyltransferase 2
by: Paeka Klaitong, et al.
Published: (2017-04-01)

Responsibility of regulatory gene expression and repressed protein synthesis for triacylglycerol accumulation on sulfur-starvation in Chlamydomonas reinhardtii
by: Atsushi eSato, et al.
Published: (2014-09-01)

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
by: Chi-Liang Eric Yen, et al.
Published: (2005-07-01)

A type-I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga, Nannochloropsis oceanica
by: Hehong Wei, et al.
Published: (2017-07-01)

Identification of Transcription Factors and the Regulatory Genes Involved in Triacylglycerol Accumulation in the Unicellular Red Alga <i>Cyanidioschyzon merolae</i>
by: Sota Takahashi, et al.
Published: (2021-05-01)

The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type
by: Toru Uyama, et al.
Published: (2009-04-01)

Occurrence of plastidial triacylglycerol synthesis and the potential regulatory role of AGPAT in the model diatom Phaeodactylum tricornutum
by: Srinivasan Balamurugan, et al.
Published: (2017-04-01)

Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by <i>Taxus</i> Acyltransferases
by: Tao Wang, et al.
Published: (2021-05-01)

Stepwise metabolic engineering of Escherichia coli to produce triacylglycerol rich in medium-chain fatty acids
by: Lin Xu, et al.
Published: (2018-06-01)

Catalytic properties of MGAT3, a putative triacylgycerol synthases⃞
by: Jingsong Cao, et al.
Published: (2007-03-01)

Expression of Castor LPAT2 Enhances Ricinoleic Acid Content at the sn-2 Position of Triacylglycerols in Lesquerella Seed
by: Grace Q. Chen, et al.
Published: (2016-04-01)

The <i>Turnera</i> Style <i>S</i>-Locus Gene <i>TsBAHD</i> Possesses Brassinosteroid-Inactivating Activity When Expressed in <i>Arabidopsis thaliana</i>
by: Courtney M. Matzke, et al.
Published: (2020-11-01)

Acyltransferases Regulate Oil Quality in Camelina sativa Through Both Acyl Donor and Acyl Acceptor Specificities
by: Ida Lager, et al.
Published: (2020-08-01)

Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes
by: Naoki Shinohara, et al.
Published: (2011-11-01)

Cottonseed Microsomal N-Acylphosphatidylethanolamine Synthase: Identification, Purification and Biochemical Characterization of a Unique Acyltransferase
by: McAndrew, Rosemary S. (Rosemary Smith)
Published: (1998)

Expression of mouse MGAT in Arabidopsis results in increased lipid accumulation in seeds
by: Anna eEl Tahchy, et al.
Published: (2015-12-01)

Studies on Hog Plasma Lecithin:cholesterol Acyltransferase: Isolation and Characterization of the Enzyme
by: Park, Yong Bok
Published: (1987)

Caractérisation de lysolipide acyltransférases chez S. cerevisiae - Apport de la Spectrométrie de Masse
by: Ayciriex, Sophie
Published: (2010)

Genetic analysis of exopolysaccharide acetilation product by Burkholderia cepacia
by: Linda Furlanis, et al.
Published: (2012-06-01)