The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice

The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice

The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 receptors (CB2R) has not been assessed. Using male mice BKS.Cg-m+...

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Bibliographic Details
Main Authors:	Christina McDonnell, Sergi Leánez, Olga Pol
Format:	Article
Language:	English
Published:	MDPI AG 2017-10-01
Series:	International Journal of Molecular Sciences
Subjects:	antinociception cannabinoid receptors diabetic neuropathy heme oxygenase 1 NAD(P)H: quinone oxidoreductase 1 Nrf2 transcription factor
Online Access:	https://www.mdpi.com/1422-0067/18/11/2268

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