Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation
Background. Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. Objective. To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. Methods. One hundred thirty patients were randomly assigned t...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2017/6082430 |
id |
doaj-f4700ad11b644dcb8c4d8625cbbf35ff |
---|---|
record_format |
Article |
spelling |
doaj-f4700ad11b644dcb8c4d8625cbbf35ff2020-11-24T21:46:33ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/60824306082430Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal CirculationPing Hua0Jianyang Liu1Jun Tao2Rongjun Zou3Xifeng Lin4Dingwen Zhang5Songran Yang6Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Vascular Surgery, Henan Provincial People’s Hospital, Zhengzhou 450003, ChinaDepartment of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaThe Biobank of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaBackground. Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. Objective. To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. Methods. One hundred thirty patients were randomly assigned to the statin group (n=65) or control group (n=65). Simvastatin was administered preoperatively and postoperatively. Duration of intensive care unit stay, duration of assisted ventilation, and left ventricular ejection fraction were recorded. Plasma was analysed for troponin T (cTnT), isoenzyme of creatine kinase (CK-MB), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8). Ultrastructure of the myocardium and autophagosomes were observed. Beclin-1, LC3-II/I, P62, AMPK, and the phosphorylation of AMPK in cardiomyocytes were detected. Results. Simvastatin significantly reduced the duration of assisted ventilation (P=0.030) and ejection fraction was significantly higher in the statin group (P=0.024). Simvastatin significantly reduced the levels of cTnT, CK-MB, TNF-α, IL-6, and IL-8 (P<0.05), reduced the expression of LC3-II/LC3-I and Beclin 1, and increased the expression of phosphorylation of AMPK. Simvastatin reduced the generation of autophagosomes and the ultrastructural injuries to myocardium. Conclusion. Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK. The registration number of this study is ChiCTR-TRC-14005164.http://dx.doi.org/10.1155/2017/6082430 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ping Hua Jianyang Liu Jun Tao Rongjun Zou Xifeng Lin Dingwen Zhang Songran Yang |
spellingShingle |
Ping Hua Jianyang Liu Jun Tao Rongjun Zou Xifeng Lin Dingwen Zhang Songran Yang Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation BioMed Research International |
author_facet |
Ping Hua Jianyang Liu Jun Tao Rongjun Zou Xifeng Lin Dingwen Zhang Songran Yang |
author_sort |
Ping Hua |
title |
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation |
title_short |
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation |
title_full |
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation |
title_fullStr |
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation |
title_full_unstemmed |
Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation |
title_sort |
efficacy and mechanism of preoperative simvastatin therapy on myocardial protection after extracorporeal circulation |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Background. Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. Objective. To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. Methods. One hundred thirty patients were randomly assigned to the statin group (n=65) or control group (n=65). Simvastatin was administered preoperatively and postoperatively. Duration of intensive care unit stay, duration of assisted ventilation, and left ventricular ejection fraction were recorded. Plasma was analysed for troponin T (cTnT), isoenzyme of creatine kinase (CK-MB), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8). Ultrastructure of the myocardium and autophagosomes were observed. Beclin-1, LC3-II/I, P62, AMPK, and the phosphorylation of AMPK in cardiomyocytes were detected. Results. Simvastatin significantly reduced the duration of assisted ventilation (P=0.030) and ejection fraction was significantly higher in the statin group (P=0.024). Simvastatin significantly reduced the levels of cTnT, CK-MB, TNF-α, IL-6, and IL-8 (P<0.05), reduced the expression of LC3-II/LC3-I and Beclin 1, and increased the expression of phosphorylation of AMPK. Simvastatin reduced the generation of autophagosomes and the ultrastructural injuries to myocardium. Conclusion. Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK. The registration number of this study is ChiCTR-TRC-14005164. |
url |
http://dx.doi.org/10.1155/2017/6082430 |
work_keys_str_mv |
AT pinghua efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT jianyangliu efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT juntao efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT rongjunzou efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT xifenglin efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT dingwenzhang efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation AT songranyang efficacyandmechanismofpreoperativesimvastatintherapyonmyocardialprotectionafterextracorporealcirculation |
_version_ |
1725901446836125696 |