The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction

The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction

The induction of autophagy, the catabolic pathway by which damaged or unnecessary cellular components are subjected to lysosome-mediated degradation and recycling, is impaired in Collagen VI (COL6) null mice and COL6-related myopathies. This autophagic impairment causes an accumulation of dysfunctio...

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Bibliographic Details
Main Authors: Samuele Metti, Lisa Gambarotto, Martina Chrisam, Martina Baraldo, Paola Braghetta, Bert Blaauw, Paolo Bonaldo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
skeletal muscle
autophagy
muscle remodeling
congenital muscular dystrophies
nutraceutical agent
Collagen VI
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.580933/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.580933/full

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