The possibilities of angiotensin receptor blocker azilsartan medoxomil and its combination with chlortalidone in cardiovascular risk decrease in patients with obesity, metabolic syndrome and diabetes mellitus

• Main Authors: Juliya V Zhernakova, Irina E Chazova, Nataliia V Blinova
• Format: Article
• Language: Russian
• Published: IP Morozov P.V. 2019-09-01
• Series: Системные гипертензии
• Subjects: arterial hypertension; obesity; metabolic syndrome; diabetes mellitus; angiotensin receptor blockers; chlortalidone; antihypertensive treatment; combined therapy; cardiovascular risk
• Online Access: https://syst-hypertension.ru/2075-082X/article/viewFile/33549/pdf

Angiotensin receptor blockers (ARBs) are with increasing frequency used in arterial hypertension treatment, this class of medications is especially important in treatment of patients with obesity, metabolic syndrome and diabetes mellitus. Although not all the ARBs are the therapy of first choice in these patients. The special requirements are imposed upon antihypertensive mediations for patients with arterial hypertension and metabolic disorders such as high antihypertensive activity, maximum duration of action, possibility of increase of peripheral tissues sensitivity to insulin and, subsequently, metabolic profile. Besides, these patients require the use of combined therapy already at the treatment start. There are very few ARBs combinations with thiazide diuretics that exhibit these properties. The present review discusses possibilities of new ARB azilsartan medoxomil (Edarbi®) and its combination with chlortalidone (Edarbi® Clo) in decrease of cardiovascular risk in patients with obesity, metabolic syndrome and diabetes mellitus.