Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients w...

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Main Authors: Wunsch Camile, Dornelles Thais Fernanda, Girardi Pricila, Arndt Marcelo Emilio, Genro Julia Pasqualini, Contini Veronica
Format: Article
Language:English
Published: Sciendo 2019-01-01
Series:Endocrine Regulations
Subjects:
coronary artery disease
risk score
t2dm
cad
association study
Online Access:https://doi.org/10.2478/enr-2019-0001
id doaj-f449a173848c4c138c07c5f4c57e5e69
record_format Article
spelling doaj-f449a173848c4c138c07c5f4c57e5e692021-09-05T21:00:49ZengSciendoEndocrine Regulations1336-03292019-01-015311710.2478/enr-2019-0001enr-2019-0001Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular diseaseWunsch Camile0Dornelles Thais Fernanda1Girardi Pricila2Arndt Marcelo Emilio3Genro Julia Pasqualini4Contini Veronica5Postgraduate Program in Biotechnology, Universidade do Vale do Taquari – Univates, Lajeado, RS, BrasilPostgraduate Program in Biotechnology, Universidade do Vale do Taquari – Univates, Lajeado, RS, BrasilPostgraduate Program in Biotechnology, Universidade do Vale do Taquari – Univates, Lajeado, RS, BrasilHemodynamic Center, Hospital Bruno Born, Lajeado, RS, BrasilPostgraduate Program in Biotechnology, Universidade do Vale do Taquari – Univates, Lajeado, RS, BrasilPostgraduate Program in Biotechnology, Universidade do Vale do Taquari – Univates, Lajeado, RS, BrasilObjective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.https://doi.org/10.2478/enr-2019-0001coronary artery diseaserisk scoret2dmcadassociation study
collection DOAJ
language English
format Article
sources DOAJ
author Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
spellingShingle Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
Endocrine Regulations
coronary artery disease
risk score
t2dm
cad
association study
author_facet Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
author_sort Wunsch Camile
title Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_short Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_full Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_fullStr Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_full_unstemmed Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_sort lack of association between tcf7l2 gene variants and type 2 diabetes mellitus in a brazilian sample of patients with the risk for cardiovascular disease
publisher Sciendo
series Endocrine Regulations
issn 1336-0329
publishDate 2019-01-01
description Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.
topic coronary artery disease
risk score
t2dm
cad
association study
url https://doi.org/10.2478/enr-2019-0001
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AT dornellesthaisfernanda lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT girardipricila lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT arndtmarceloemilio lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT genrojuliapasqualini lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT continiveronica lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
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