Death switch for gene therapy: application to erythropoietin transgene expression

Death switch for gene therapy: application to erythropoietin transgene expression

The effectiveness of the caspase-9-based artificial "death switch" as a safety measure for gene therapy based on the erythropoietin (Epo) hormone was tested in vitro and in vivo using the chemical inducer of dimerization, AP20187. Plasmids encoding the dimeric murine Epo, the tetracycline-...

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Bibliographic Details
Main Authors: D.S. Souza, D.M. Spencer, T.S.I. Salles, M.A. Salomão, E. Payen, Y. Beuzard, H.F. Carvalho, F.F. Costa, S.T.Olalla Saad
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Gene therapy
Erythropoietin
Death switch
Caspase 9
AP20187
Anemia
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700005

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