Identification of a G-Protein-Independent Activator of GIRK Channels

Identification of a G-Protein-Independent Activator of GIRK Channels

Summary: G-protein-gated inwardly rectifying K+ (GIRK) channels are essential effectors of inhibitory neurotransmission in the brain. GIRK channels have been implicated in diseases with abnormal neuronal excitability, including epilepsy and addiction. GIRK channels are tetramers composed of either t...

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Bibliographic Details
Main Authors: Yulin Zhao, Peter Man-Un Ung, Gergely Zahoránszky-Kőhalmi, Alexey V. Zakharov, Natalia J. Martinez, Anton Simeonov, Ian W. Glaaser, Ganesha Rai, Avner Schlessinger, Juan J. Marugan, Paul A. Slesinger
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
G-protein-gated inwardly rectifying K+ channel
GIRK1-selective activator
alcohol-like kinetics
antiseizure
epilepsy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307506

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http://www.sciencedirect.com/science/article/pii/S2211124720307506

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