Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells.

Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells.

Inducible Co-stimulator (ICOS) plays a critical role in mediating T cell differentiation and function and is considered a key player in balancing T effector and T regulatory (Treg) cell responses. Here we show that activation of the ICOS signalling pathway during acute influenza A virus (IAV) infect...

Full description

Bibliographic Details
Main Authors: Priya Sakthivel, Marcus Gereke, Angele Breithaupt, Dietmar Fuchs, Luca Gigliotti, Achim D Gruber, Umberto Dianzani, Dunja Bruder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4100737?pdf=render

Internet

http://europepmc.org/articles/PMC4100737?pdf=render

Similar Items