PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes

PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes

Although it is widely accepted that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are readily available, robustly reproducible, and physiologically appropriate human cells for clinical applications and research in the cardiovascular field, hiPSC-CMs cultured in vitro retain...

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Bibliographic Details
Main Authors: Qin Zhou, Hao Xu, Liang Yan, Liang Ye, Xinyuan Zhang, Bin Tan, Qin Yi, Jie Tian, Jing Zhu
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Genes and Diseases
Subjects:
Cardiac differentiation
hiPSCs
Mitochondrial metabolism
PGC-1α
Maturation
Online Access:http://www.sciencedirect.com/science/article/pii/S235230422030163X

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