FEATURES OF CELLULAR AND HUMORAL IMMUNITY IN ACUTE AND CHRONIC VIRAL HEPATITIS В

• Main Authors: A. G. Borisov, A. A. Savchenko
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2012-05-01
• Series: Acta Biomedica Scientifica
• Subjects: hepatitis; lymphocytes; immunoglobulins
• Online Access: https://www.actabiomedica.ru/jour/article/view/884

We investigated immunological paгameters in patients with acute (AVHB) and chronic hepatitis B. It is established that changing the values of immunological parameters can determine the nature of the infection couse in chronic viral hepatitis B and select at least two types of immune response. The first type (hyperergic) is characterized by high values of immunological indicator, determined by increasing the content of CD3+-lymphocytes with a dysregulation in the subpopulation of T-cells and an increase in humoral immunity. The second (hypoergic) — decrease in the number of T-cells, CD4+- and CD8+-lymphocytes, and various types of immunoglobulins. When AVHB development of acute infection is associated with a reduction in the number of T-lymphocytes, mainly due to the population of CD4+-lymphocytes, increased concentration of immunoglobulins and the CIC, which also indicates the hypoergic type of immune response in acute viral infection.