| Summary: | Abstract Background Diffeomorphic demons can not only guarantee smooth and reversible deformation, but also avoid unreasonable deformation. However, the number of iterations which has great influence on the registration result needs to be set manually. Methods This study proposed a novel method to exploit the adaptive diffeomorphic multi-resolution demons algorithm to the non-rigid registration of the same modality medical images with large deformation. Firstly an optimized non-rigid registration framework and the diffeomorphism strategy were used, and then a similarity energy function based on the grey value was designed as registration metric, lastly termination condition was set based on the variation of this metric and iterations can be stopped adaptively. Quantitative analyses based on the registration evaluation indexes were conducted to prove the validity of this method. Results Registration result of synthetic image and the same modality MRI and CT image was compared with those obtained by other demons algorithms. Quantitative analyses demonstrated the proposed method’s superiority. Medical image with large deformation was produced by rotational distortion and extrusion transform, and the same modality image registration with large deformation was performed successfully. Quantitative analyses showed that the registration evaluation indexes remained stable with an increase in transform strength. This method can be also applied to pulmonary medical image registration with large deformation successfully, and it showed the clinical application value. The influence of different driving forces and parameters on the registration result was analysed, and the result demonstrated that the proposed method is effective and robust. Conclusions This method can solve the non-rigid registration problem of the same modality medical image with large deformation showing promise for diagnostic pulmonary imaging applications.
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