Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin

Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resul...

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Main Authors:	José M. Olmos-Martínez, Helena Molina, Cristina Salas, José M. Olmos, José L. Hernández
Format:	Article
Language:	English
Published:	SMC MEDIA SRL 2019-03-01
Series:	European Journal of Case Reports in Internal Medicine
Subjects:	Colchicine neuromyopathy atorvastatin clarithromycin
Online Access:	https://www.ejcrim.com/index.php/EJCRIM/article/view/1066

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spelling	doaj-f416363e5f0e440b8099b47ad75fa67f2020-11-25T02:15:10ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942019-03-0110.12890/2019_0010661066Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and ClarithromycinJosé M. Olmos-Martínez0Helena Molina1Cristina Salas2José M. Olmos3José L. Hernández4Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, SpainDepartment of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, SpainDepartment of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, SpainDepartment of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, SpainDepartment of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, SpainNeuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy.https://www.ejcrim.com/index.php/EJCRIM/article/view/1066Colchicineneuromyopathyatorvastatinclarithromycin
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	José M. Olmos-Martínez Helena Molina Cristina Salas José M. Olmos José L. Hernández
spellingShingle	José M. Olmos-Martínez Helena Molina Cristina Salas José M. Olmos José L. Hernández Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin European Journal of Case Reports in Internal Medicine Colchicine neuromyopathy atorvastatin clarithromycin
author_facet	José M. Olmos-Martínez Helena Molina Cristina Salas José M. Olmos José L. Hernández
author_sort	José M. Olmos-Martínez
title	Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
title_short	Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
title_full	Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
title_fullStr	Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
title_full_unstemmed	Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
title_sort	acute colchicine-induced neuromyopathy in a patient treated with atorvastatin and clarithromycin
publisher	SMC MEDIA SRL
series	European Journal of Case Reports in Internal Medicine
issn	2284-2594
publishDate	2019-03-01
description	Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy.
topic	Colchicine neuromyopathy atorvastatin clarithromycin
url	https://www.ejcrim.com/index.php/EJCRIM/article/view/1066
work_keys_str_mv	AT josemolmosmartinez acutecolchicineinducedneuromyopathyinapatienttreatedwithatorvastatinandclarithromycin AT helenamolina acutecolchicineinducedneuromyopathyinapatienttreatedwithatorvastatinandclarithromycin AT cristinasalas acutecolchicineinducedneuromyopathyinapatienttreatedwithatorvastatinandclarithromycin AT josemolmos acutecolchicineinducedneuromyopathyinapatienttreatedwithatorvastatinandclarithromycin AT joselhernandez acutecolchicineinducedneuromyopathyinapatienttreatedwithatorvastatinandclarithromycin
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Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin

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