The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass

The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass

Abstract Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5′ terminal oligopyrimidine tract (5′TOP) mRNAs which encode protei...

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Bibliographic Details
Main Authors: Joao Pedro Werneck-de-Castro, Flavia Leticia Martins Peçanha, Diego Henrique Silvestre, Ernesto Bernal-Mizrachi
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81457-4

Internet

https://doi.org/10.1038/s41598-021-81457-4

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