Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response

Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response

Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who de...

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Main Authors: Lila Aboueid, Richard H. McCarthy
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2016/6123913
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spelling doaj-f404443a460d4882941e3ec209644e092020-11-24T20:44:47ZengHindawi LimitedCase Reports in Psychiatry2090-682X2090-68382016-01-01201610.1155/2016/61239136123913Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine ResponseLila Aboueid0Richard H. McCarthy1SUNY Downstate Medical Center, Department of Psychiatry, 450 Clarkson Avenue, Brooklyn, NY 11203, USAKingsboro Psychiatric Center, 681 Clarkson Avenue, Brooklyn, NY 11203, USAClozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who developed clozapine-induced agranulocytosis after 10 weeks of clozapine treatment and was subsequently successfully treated with a combination of loxapine and cyproheptadine. The combination is thought to mimic the pharmacological profile of clozapine, rendering it as a possible alternative to traditional clozapine treatment.http://dx.doi.org/10.1155/2016/6123913
collection DOAJ
language English
format Article
sources DOAJ
author Lila Aboueid
Richard H. McCarthy
spellingShingle Lila Aboueid
Richard H. McCarthy
Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
Case Reports in Psychiatry
author_facet Lila Aboueid
Richard H. McCarthy
author_sort Lila Aboueid
title Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_short Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_full Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_fullStr Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_full_unstemmed Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response
title_sort loxapine and cyproheptadine combined limit clozapine rebound psychosis and may also predict clozapine response
publisher Hindawi Limited
series Case Reports in Psychiatry
issn 2090-682X
2090-6838
publishDate 2016-01-01
description Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who developed clozapine-induced agranulocytosis after 10 weeks of clozapine treatment and was subsequently successfully treated with a combination of loxapine and cyproheptadine. The combination is thought to mimic the pharmacological profile of clozapine, rendering it as a possible alternative to traditional clozapine treatment.
url http://dx.doi.org/10.1155/2016/6123913
work_keys_str_mv AT lilaaboueid loxapineandcyproheptadinecombinedlimitclozapinereboundpsychosisandmayalsopredictclozapineresponse
AT richardhmccarthy loxapineandcyproheptadinecombinedlimitclozapinereboundpsychosisandmayalsopredictclozapineresponse
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