The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation

The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation

Abstract Background Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with large negative intrathoracic pressures, due to strenuous contractions of the inspiratory muscles. IRB is shown to induce lung injury in previously healthy animals. Src is a multif...

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Bibliographic Details
Main Authors: Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Ioanna Sigala, Panagiotis Zacharatos, Ioanna Vraila, Vassiliki Karavana, Stamatios Theocharis, Theodoros Vassilakopoulos
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Respiratory Research
Subjects:
Src
ERK1/2
Resistive breathing
Lung injury
Online Access:http://link.springer.com/article/10.1186/s12931-017-0694-7

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