Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway

Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway

Background: Patients with metastatic radioiodine-refractory papillary thyroid carcinoma (PTC) have limited treatment options and a poor prognosis. There is an urgent need to develop new drugs targeting PTC for clinical application. Apatinib, a novel small-molecule tyrosine kinase inhibitor (TKI), is...

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Bibliographic Details
Main Authors: Xiangrui Meng, Huijuan Wang, Jingzhu Zhao, Linfei Hu, Jingtai Zhi, Songfeng Wei, Xianhui Ruan, Xiukun Hou, Dapeng Li, Jun Zhang, Weiwei Yang, Biyun Qian, Yu Wu, Yuan Zhang, Zhaowei Meng, Lizhao Guan, Huilai Zhang, Xiangqian Zheng, Ming Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
apatinib
papillary thyroid carcinoma
PI3K
apoptosis
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00217/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00217/full

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