Role of mutational reversions and fitness restoration in Zika virus spread to the Americas

The trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asi...

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Main Authors:	Jianying Liu, Yang Liu, Chao Shan, Bruno T. D. Nunes, Ruimei Yun, Sherry L. Haller, Grace H. Rafael, Sasha R. Azar, Clark R. Andersen, Kenneth Plante, Nikos Vasilakis, Pei-Yong Shi, Scott C. Weaver
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20747-3

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spelling	doaj-f3efba102a884e04b70d3b7ef247c0bf2021-01-31T12:19:28ZengNature Publishing GroupNature Communications2041-17232021-01-0112111210.1038/s41467-020-20747-3Role of mutational reversions and fitness restoration in Zika virus spread to the AmericasJianying Liu0Yang Liu1Chao Shan2Bruno T. D. Nunes3Ruimei Yun4Sherry L. Haller5Grace H. Rafael6Sasha R. Azar7Clark R. Andersen8Kenneth Plante9Nikos Vasilakis10Pei-Yong Shi11Scott C. Weaver12World Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology and Institute for Human Infections and Immunity, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology and Institute for Human Infections and Immunity, University of Texas Medical BranchDepartment of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of HealthWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchDepartment of Preventive Medicine and Community Health, University of Texas Medical BranchWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchDepartment of Pathology, Center for Biodefense and Emerging Infectious Diseases, World Reference Center for Emerging Viruses and Arboviruses, and Institute for Human Infections and Immunity, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology and Institute for Human Infections and Immunity, University of Texas Medical BranchWorld Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical BranchThe trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asia, and show in experimental infections of mosquitoes, human cells, and mice that the original mutations reduced fitness for urban transmission, while the reversions restored fitness, likely increasing epidemic risk.https://doi.org/10.1038/s41467-020-20747-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver
spellingShingle	Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver Role of mutational reversions and fitness restoration in Zika virus spread to the Americas Nature Communications
author_facet	Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver
author_sort	Jianying Liu
title	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_short	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_full	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_fullStr	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_full_unstemmed	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_sort	role of mutational reversions and fitness restoration in zika virus spread to the americas
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	The trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asia, and show in experimental infections of mosquitoes, human cells, and mice that the original mutations reduced fitness for urban transmission, while the reversions restored fitness, likely increasing epidemic risk.
url	https://doi.org/10.1038/s41467-020-20747-3
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Role of mutational reversions and fitness restoration in Zika virus spread to the Americas

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