Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus

Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus

Current therapeutics for chronic infection with hepatitis B virus (HBV) rarely induce functional cure due to the immunotolerant status of patients. Small molecule agonists targeting toll‐like receptor 7 (TLR7) have been shown to elicit a functional cure in animal models of HBV but sometimes with poo...

Full description

Bibliographic Details
Main Authors:	Kyle E. Korolowizc, Bin Li, Xu Huang, Changsuek Yon, Evelyn Rodrigo, Manny Corpuz, David M. Plouffe, Bhaskar V. Kallakury, Manasa Suresh, Tom Y.‐H. Wu, Andrew T. Miller, Stephan Menne
Format:	Article
Language:	English
Published:	Wiley 2019-10-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1397

Similar Items

Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis B
by: Kyle E. Korolowicz, et al.
Published: (2021-04-01)

Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon‐α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus
by: Stephan Menne, et al.
Published: (2020-06-01)

Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks.
by: Manasa Suresh, et al.
Published: (2017-01-01)

Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks
by: Kyle E. Korolowicz, et al.
Published: (2021-09-01)

Innate and adaptive immunity associated with resolution of acute woodchuck hepatitis virus infection in adult woodchucks.
by: Manasa Suresh, et al.
Published: (2019-12-01)

Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects
by: Manasa Suresh, et al.
Published: (2021-10-01)

Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks
by: Manasa Suresh, et al.
Published: (2021-07-01)

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra‐arterial therapies
by: Alexander Y. Kim, et al.
Published: (2020-03-01)

Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B.
by: Kyle E Korolowicz, et al.
Published: (2016-01-01)

Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model.
by: Anna D Kosinska, et al.
Published: (2013-01-01)

Heavy Minerals for Junior Woodchucks
by: Eduardo Garzanti, et al.
Published: (2019-02-01)

AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B.
by: Daniela Paulsen, et al.
Published: (2015-01-01)

The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies
by: Janne Tegder Martinsen, et al.
Published: (2020-06-01)

Dynamic Computed Tomography in Woodchuck Hepatoma Model
by: I-Lun Shih, et al.
Published: (2012)

Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.
by: Scott Balsitis, et al.
Published: (2018-01-01)

The Genome Sequence of the Eastern Woodchuck (Marmota monax) – A Preclinical Animal Model for Chronic Hepatitis B
by: Tyler S. Alioto, et al.
Published: (2019-12-01)

Differential Expression of Woodchuck Toll-Like Receptors 1–10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection
by: John Bradley Williams, et al.
Published: (2018-12-01)

Persistence of the recombinant genomes of woodchuck hepatitis virus in the mouse model.
by: Danzhen Pan, et al.
Published: (2015-01-01)

The Effect of Urbanization on Flight Initiation Distance and Alert Behaviors in Woodchucks
by: Lippmann, Kiersten Elizabeth
Published: (2009)

Imaging, Pathology, and Immune Correlates in the Woodchuck Hepatic Tumor Model
by: Mauda-Havakuk M, et al.
Published: (2021-03-01)

Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
by: Simon P Fletcher, et al.
Published: (2015-09-01)

Adipose tissue cellularity in woodchucks: effects of season and captivity at an early age
by: R A Young, et al.
Published: (1982-08-01)

Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
by: Simon P Fletcher, et al.
Published: (2016-03-01)

Entecavir in clinical practice
by: Editorial Article
Published: (2018-08-01)

Magnetic resonance characterization of hepatocellular carcinoma in the woodchuck model of chronic viral hepatitis
by: McKenzie, Eilean J
Published: (2009)

Magnetic resonance characterization of hepatocellular carcinoma in the woodchuck model of chronic viral hepatitis
by: McKenzie, Eilean J
Published: (2009)

Magnetic resonance characterization of hepatocellular carcinoma in the woodchuck model of chronic viral hepatitis
by: McKenzie, Eilean J
Published: (2009)

Toll-Like Receptor 9 Agonists in Cancer
by: Karapetyan L, et al.
Published: (2020-10-01)

Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy
by: Max E. Kirtland, et al.
Published: (2020-11-01)

Toll-Like Receptor 9 Agonists for Cancer Therapy
by: Davide Melisi, et al.
Published: (2014-08-01)

Performance evaluation of the HepB Typer-Entecavir kit for detection of entecavir resistance mutations in chronic hepatitis B
by: Sang Hoon Ahn, et al.
Published: (2013-12-01)

Sequential therapy from entecavir to tenofovir alafenamide versus continuous entecavir monotherapy for patients with chronic hepatitis B
by: Norio Itokawa, et al.
Published: (2021-01-01)

Toll like receptors agonists-based nanomedicines as veterinary immunotherapies
by: Eder L Romero, et al.

Trial Watch: Toll-like receptor agonists in cancer immunotherapy
by: Melody Smith, et al.
Published: (2018-12-01)

Anti-tumor Activity of Toll-Like Receptor 7 Agonists
by: Huju Chi, et al.
Published: (2017-05-01)

The toll-like receptor agonist imiquimod is active against prions.
by: Nassima Oumata, et al.
Published: (2013-01-01)

Experience of entecavir therapy in chronic hepatitis B
by: E. V. Esaulenko, et al.
Published: (2014-09-01)

Entecavir for the treatment of chronic hepatitis B infection
by: J Shepherd, et al.
Published: (2009-10-01)

Severe Acute Hepatitis B Treated with Entecavir
by: Giuseppe Vittorio Luigi De Socio, et al.
Published: (2011-03-01)

Severe Acute Hepatitis B Treated with Entecavir
by: Andrea Tosti, et al.
Published: (2011-01-01)

Cannot write session to /tmp/vufind_sessions/sess_ubeue6t167tor0jl4f5bj5hacj