Analysis of efficacy of travoprost with a preservative polyquad in the treatment of patients with primary open-angle glaucoma

• Main Authors: Petrova Yu.V., Veselova E.V.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2015-09-01
• Series: Саратовский научно-медицинский журнал
• Subjects: benzalkonium chloride; histomorphological changes in the corneal tissue; polyquad; primary open-angle glaucoma
• Online Access: http://www.ssmj.ru/system/files/2015_03_337-341.pdf

The purpose was to evaluate the efficacy and tolerability of travoprost and timolol use in the treatment of patients with initial stage of primary open angle glaucoma (POAG), as well as a preservative effect on the state of the cornea. Material and Methods. We observed 30 patients with a diagnosis of POAG first revealed. Group 1 patients (24 eyes) afforded 0.004% solution travoprost, patients in Group 2 (16 eyes) — 0.5% solution of timolol maleate. Patients in Group 1 who received travoprost with ВАК were administered travoprost with preservative polyquad in the same mode instillation. After 3 months after changing medication patients underwent examination of the cornea by laser scanning confocal imaging. Results. Intraocular pressure (IOP) in patients in Group 1 dropped from 33±3mm Hg. Article 18±2mm Hg.Art. In group 2, IOP decreased from 32±2mm Hg. to 21 ±1,5 mm Hg. Art. After 3 months of treatment with travoprost polyquad total number of epithelial cells of the cornea increased to 6231 ±415 cells/ mm2, signs of edema were not detected in 18 of 24 eyes in 6 cases, swelling of the corneal epithelium decreased, decreased number of "bright" keratocytes, endothelial cells well visualized and of hexagonal shape. Conclusion. Application of travoprost in patients with POAG provides a marked hypotensive effect compared with timolol. Application of travoprost with polyquad improves the state of the front layers of the epithelium and the corneal stroma of patients with glaucoma, reduced patients complaints to sensation of a foreign body and eye discomfort and redness.