MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma

MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma

Septic encephalopathy is a frequent complication of sepsis, but there are few studies examining the role of microRNAs (miRs) in its pathogenesis. In this study, a miR-219 mimic was transfected into rat hippocampal neurons to model miR-219 overexpression. A protective effect of miR-219 was observed f...

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Bibliographic Details
Main Authors: Ting Wang, Qun Cai, Wen-Jie Yang, Hai-Hua Fan, Jian-Feng Yi, Feng Xu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; brain injury; septic encephalopathy; miR-219; hippocampal neurons; glutamate; excitotoxicity; apoptosis; caspase-3; calmodulin-dependent protein kinase II γ; luciferase reporter gene system; neuroprotection; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=7;spage=1216;epage=1224;aulast=Wang

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