Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

ABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.

Bibliographic Details
Main Authors: Qin Yu, Dongchun Ni, Julia Kowal, Ioannis Manolaridis, Scott M. Jackson, Henning Stahlberg, Kaspar P. Locher
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24651-2
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spelling doaj-f3dae0a3a07a42eb9d31262f294b25052021-07-25T11:39:01ZengNature Publishing GroupNature Communications2041-17232021-07-0112111210.1038/s41467-021-24651-2Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanismQin Yu0Dongchun Ni1Julia Kowal2Ioannis Manolaridis3Scott M. Jackson4Henning Stahlberg5Kaspar P. Locher6Institute of Molecular Biology and Biophysics, Department of Biology, ETH ZürichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselInstitute of Molecular Biology and Biophysics, Department of Biology, ETH ZürichInstitute of Molecular Biology and Biophysics, Department of Biology, ETH ZürichInstitute of Molecular Biology and Biophysics, Department of Biology, ETH ZürichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselInstitute of Molecular Biology and Biophysics, Department of Biology, ETH ZürichABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.https://doi.org/10.1038/s41467-021-24651-2
collection DOAJ
language English
format Article
sources DOAJ
author Qin Yu
Dongchun Ni
Julia Kowal
Ioannis Manolaridis
Scott M. Jackson
Henning Stahlberg
Kaspar P. Locher
spellingShingle Qin Yu
Dongchun Ni
Julia Kowal
Ioannis Manolaridis
Scott M. Jackson
Henning Stahlberg
Kaspar P. Locher
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
Nature Communications
author_facet Qin Yu
Dongchun Ni
Julia Kowal
Ioannis Manolaridis
Scott M. Jackson
Henning Stahlberg
Kaspar P. Locher
author_sort Qin Yu
title Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
title_short Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
title_full Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
title_fullStr Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
title_full_unstemmed Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
title_sort structures of abcg2 under turnover conditions reveal a key step in the drug transport mechanism
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description ABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.
url https://doi.org/10.1038/s41467-021-24651-2
work_keys_str_mv AT qinyu structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT dongchunni structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT juliakowal structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT ioannismanolaridis structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT scottmjackson structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT henningstahlberg structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
AT kasparplocher structuresofabcg2underturnoverconditionsrevealakeystepinthedrugtransportmechanism
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