Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

BACKGROUND:Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression. OBJECTIVE:To perform a GWAS using a well-characterized cohort to detect single nucleotide polymorphisms (SNPs) and gene...

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Main Authors: Xutao Deng, Ester C Sabino, Edecio Cunha-Neto, Antonio L Ribeiro, Barbara Ianni, Charles Mady, Michael P Busch, Mark Seielstad, REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3854669?pdf=render

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