Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks

Perturbation of biological networks is often observed during exposure to xenobiotics, and the identification of disturbed processes, their dynamic traits, and dose–response relationships are some of the current challenges for elucidating the mechanisms determining adverse outcomes. In this scenario,...

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Bibliographic Details
Main Authors: Terezinha M. Souza, Jos C. S. Kleinjans, Danyel G. J. Jennen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00142/full