Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency

Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency

Pancreatic insufficiency leading to altered cyclosporine absorption is reported in a 37-year-old man with ulcerative colitis and sclerosing cholangitis. Asymptomatic chronic pancreatitis occurs frequently in patients with ulcerative colitis, and even more commonly when there is coexistent sclerosing...

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Main Authors: Mark G Swain, Helga Witt-Sullivan, Richard Ogilvie, Ian Wanless, Jenny Heathcote
Format: Article
Language:English
Published: Hindawi Limited 1991-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1991/532037
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spelling doaj-f3c2b01e03d5467d968c8ddd6f478cc02020-11-25T00:32:48ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001991-01-015413313610.1155/1991/532037Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic InsufficiencyMark G Swain0Helga Witt-Sullivan1Richard Ogilvie2Ian Wanless3Jenny Heathcote4Departments of Medicine, Pharmacology and Pathology, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine, Pharmacology and Pathology, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine, Pharmacology and Pathology, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine, Pharmacology and Pathology, University of Toronto, Toronto, Ontario, CanadaDepartments of Medicine, Pharmacology and Pathology, University of Toronto, Toronto, Ontario, CanadaPancreatic insufficiency leading to altered cyclosporine absorption is reported in a 37-year-old man with ulcerative colitis and sclerosing cholangitis. Asymptomatic chronic pancreatitis occurs frequently in patients with ulcerative colitis, and even more commonly when there is coexistent sclerosing cholangitis. However, pancreatic insufficiency has been documented in only one patient previously with ulcerative colitis and sclerosing cholangitis. Pancreatic function testing can help to identify the complex etiology of malabsorption in these patients and is recommended in patients when liver transplantation is contemplated, as pancreatic insufficiency may alter the absorption of cyclosporine.http://dx.doi.org/10.1155/1991/532037
collection DOAJ
language English
format Article
sources DOAJ
author Mark G Swain
Helga Witt-Sullivan
Richard Ogilvie
Ian Wanless
Jenny Heathcote
spellingShingle Mark G Swain
Helga Witt-Sullivan
Richard Ogilvie
Ian Wanless
Jenny Heathcote
Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
Canadian Journal of Gastroenterology
author_facet Mark G Swain
Helga Witt-Sullivan
Richard Ogilvie
Ian Wanless
Jenny Heathcote
author_sort Mark G Swain
title Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
title_short Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
title_full Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
title_fullStr Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
title_full_unstemmed Altered Cyclosporine Absorption in a Patient with Ulcerative Colitis, Sclerosing Cholangitis and Pancreatic Insufficiency
title_sort altered cyclosporine absorption in a patient with ulcerative colitis, sclerosing cholangitis and pancreatic insufficiency
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1991-01-01
description Pancreatic insufficiency leading to altered cyclosporine absorption is reported in a 37-year-old man with ulcerative colitis and sclerosing cholangitis. Asymptomatic chronic pancreatitis occurs frequently in patients with ulcerative colitis, and even more commonly when there is coexistent sclerosing cholangitis. However, pancreatic insufficiency has been documented in only one patient previously with ulcerative colitis and sclerosing cholangitis. Pancreatic function testing can help to identify the complex etiology of malabsorption in these patients and is recommended in patients when liver transplantation is contemplated, as pancreatic insufficiency may alter the absorption of cyclosporine.
url http://dx.doi.org/10.1155/1991/532037
work_keys_str_mv AT markgswain alteredcyclosporineabsorptioninapatientwithulcerativecolitissclerosingcholangitisandpancreaticinsufficiency
AT helgawittsullivan alteredcyclosporineabsorptioninapatientwithulcerativecolitissclerosingcholangitisandpancreaticinsufficiency
AT richardogilvie alteredcyclosporineabsorptioninapatientwithulcerativecolitissclerosingcholangitisandpancreaticinsufficiency
AT ianwanless alteredcyclosporineabsorptioninapatientwithulcerativecolitissclerosingcholangitisandpancreaticinsufficiency
AT jennyheathcote alteredcyclosporineabsorptioninapatientwithulcerativecolitissclerosingcholangitisandpancreaticinsufficiency
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