Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-lik...
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Elsevier
2019-07-01
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| Series: | New Microbes and New Infections |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S205229751930040X |
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doaj-f3bd1b584f97442cab0a9e5a5cbece282020-11-25T01:16:35ZengElsevierNew Microbes and New Infections2052-29752019-07-0130Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patientN.D. Ramdhan0J. Blom1I.C. Sutcliffe2P.M.A. Pereira-Ribeiro3C.S. Santos4A.L. Mattos-Guaraldi5A. Burkovski6V. Sangal7Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UKBioinformatics and Systems Biology, Justus-Liebig-Universität, Gießen, GermanyFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UKLaboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University–UERJ, Rio de Janeiro, BrazilLaboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University–UERJ, Rio de Janeiro, BrazilLaboratory of Diphtheria and Corynebacteria of Clinical Relevance-LDCIC, Faculty of Medical Sciences, Rio de Janeiro State University–UERJ, Rio de Janeiro, BrazilDepartment of Microbiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, England, UK; Corresponding author: V. Sangal, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, England, UK.The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics. Keywords: Adenoid cystic carcinoma, Corynebacterium diphtheriae, invasive infection, nontoxigenic, virulencehttp://www.sciencedirect.com/science/article/pii/S205229751930040X |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
N.D. Ramdhan J. Blom I.C. Sutcliffe P.M.A. Pereira-Ribeiro C.S. Santos A.L. Mattos-Guaraldi A. Burkovski V. Sangal |
| spellingShingle |
N.D. Ramdhan J. Blom I.C. Sutcliffe P.M.A. Pereira-Ribeiro C.S. Santos A.L. Mattos-Guaraldi A. Burkovski V. Sangal Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient New Microbes and New Infections |
| author_facet |
N.D. Ramdhan J. Blom I.C. Sutcliffe P.M.A. Pereira-Ribeiro C.S. Santos A.L. Mattos-Guaraldi A. Burkovski V. Sangal |
| author_sort |
N.D. Ramdhan |
| title |
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient |
| title_short |
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient |
| title_full |
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient |
| title_fullStr |
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient |
| title_full_unstemmed |
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient |
| title_sort |
genomic analysis of a novel nontoxigenic corynebacterium diphtheriae strain isolated from a cancer patient |
| publisher |
Elsevier |
| series |
New Microbes and New Infections |
| issn |
2052-2975 |
| publishDate |
2019-07-01 |
| description |
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics. Keywords: Adenoid cystic carcinoma, Corynebacterium diphtheriae, invasive infection, nontoxigenic, virulence |
| url |
http://www.sciencedirect.com/science/article/pii/S205229751930040X |
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