Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

• Main Authors: Yangqing Chen, Yong Liu, Xiaodan Shen, Zhimin Chang, Longhua Tang, Wen-Fei Dong, Mingyu Li, Jian-Jun He
• Format: Article
• Language: English
• Published: MDPI AG 2015-12-01
• Series: Sensors
• Subjects: Microring resonator; Molecularly imprinted polymers; Testosterone
• Online Access: http://www.mdpi.com/1424-8220/15/12/29877
• ISSN: 1424-8220

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.