Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

Bifunctional 8-oxoguanine-DNA glycosylase (OGG1), a crucial DNA-repair enzyme, removes from DNA 8-oxo-7,8-dihydroguanine (8-oxoG) with following cleavage of the arising apurinic/apyrimidinic (AP) site. The major enzyme in eukaryotic cells that catalyzes the cleavage of AP sites is AP endonuclease 1...

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Bibliographic Details
Main Authors: Natalia A. Lebedeva, Nadejda I. Rechkunova, Anton V. Endutkin, Olga I. Lavrik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
apurinic/apyrimidinic site
8-oxoguanine-DNA glycosylase
AP endonuclease 1
tyrosyl-DNA phosphodiesterase 1
poly(ADP-ribose) polymerases
DNA-protein crosslinks
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.617301/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.617301/full

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