Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.

Autophagy and phagocytosis are cellular immune mechanisms for internalization and elimination of intracellular and extracellular pathogens. Some pathogens have evolved the ability to inhibit or manipulate these processes, raising the prospect of adaptive reciprocal co-evolution by the host. We perfo...

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Main Authors: Joo Hyun Im, Brian P Lazzaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6169979?pdf=render
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spelling doaj-f3b2625e3907421aaa5ffa9c9d00aa8c2020-11-25T01:27:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020502410.1371/journal.pone.0205024Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.Joo Hyun ImBrian P LazzaroAutophagy and phagocytosis are cellular immune mechanisms for internalization and elimination of intracellular and extracellular pathogens. Some pathogens have evolved the ability to inhibit or manipulate these processes, raising the prospect of adaptive reciprocal co-evolution by the host. We performed population genetic analyses on phagocytosis and autophagy genes in Drosophila melanogaster and D. simulans to test for molecular evolutionary signatures of immune adaptation. We found that phagocytosis and autophagy genes as a whole exhibited an elevated level of haplotype homozygosity in both species. In addition, we detected signatures of recent selection, notably in the Atg14 and Ykt6 genes in D. melanogaster and a pattern of elevated sequence divergence in the genderblind (gb) gene on the D. simulans lineage. These results suggest that the evolution of the host cellular immune system as a whole may be shaped by a dynamic conflict between Drosophila and its pathogens even without pervasive evidence of strong adaptive evolution at the individual gene level.http://europepmc.org/articles/PMC6169979?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Joo Hyun Im
Brian P Lazzaro
spellingShingle Joo Hyun Im
Brian P Lazzaro
Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
PLoS ONE
author_facet Joo Hyun Im
Brian P Lazzaro
author_sort Joo Hyun Im
title Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
title_short Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
title_full Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
title_fullStr Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
title_full_unstemmed Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.
title_sort population genetic analysis of autophagy and phagocytosis genes in drosophila melanogaster and d. simulans.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description Autophagy and phagocytosis are cellular immune mechanisms for internalization and elimination of intracellular and extracellular pathogens. Some pathogens have evolved the ability to inhibit or manipulate these processes, raising the prospect of adaptive reciprocal co-evolution by the host. We performed population genetic analyses on phagocytosis and autophagy genes in Drosophila melanogaster and D. simulans to test for molecular evolutionary signatures of immune adaptation. We found that phagocytosis and autophagy genes as a whole exhibited an elevated level of haplotype homozygosity in both species. In addition, we detected signatures of recent selection, notably in the Atg14 and Ykt6 genes in D. melanogaster and a pattern of elevated sequence divergence in the genderblind (gb) gene on the D. simulans lineage. These results suggest that the evolution of the host cellular immune system as a whole may be shaped by a dynamic conflict between Drosophila and its pathogens even without pervasive evidence of strong adaptive evolution at the individual gene level.
url http://europepmc.org/articles/PMC6169979?pdf=render
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