Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons (MNs). Approximately 10% of ALS cases are familial (known as FALS), and ∼20% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase type 1 (SOD1). Mutant (MT) SOD1 ind...

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Bibliographic Details
Main Authors: Lijun Wang, Kamal Sharma, Han-Xiang Deng, Teepu Siddique, Gabriella Grisotti, Erdong Liu, Raymond P. Roos
Format: Article
Language:English
Published: Elsevier 2008-03-01
Series:Neurobiology of Disease
Subjects:
Familial amyotrophic lateral sclerosis
ALS
Mutant Cu/Zn superoxide dismutase type 1 (SOD1)
Motor neurons
Degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002367

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