Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy

Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy

Lamotrigine (LTG) is a second-generation anti-epileptic drug widely used for focal and generalized seizures in adults and children, and as a first-line medication in pregnant women and women of childbearing age. However, LTG pharmacokinetics shows high inter-individual variability, thus potentially...

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Bibliographic Details
Main Authors: Zhan-zhang Wang, Yue-feng Zhang, Wen-can Huang, Xi-pei Wang, Xiao-jiao Ni, Hao-yang Lu, Jin-qing Hu, Shu-hua Deng, Xiu-qing Zhu, Huan-shan Xie, Hong-zhen Chen, Ming Zhang, Chang Qiu, Yu-guan Wen, De-wei Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
lamotrigine
Chinese
population pharmacokinetics
NONMEM
epilepsy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00832/full

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