Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of...

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Main Authors:	Viviana L. Vedder, Zouhair Aherrahrou, Jeanette Erdmann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	atherosclerosis animal models mouse zebrafish immune response human disease
Online Access:	https://www.frontiersin.org/article/10.3389/fcvm.2020.00109/full

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spelling	doaj-f3ac9eb3866d49fc8039c4631691ec1b2020-11-25T02:18:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-06-01710.3389/fcvm.2020.00109533083Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and ZebrafishViviana L. Vedder0Viviana L. Vedder1Viviana L. Vedder2Zouhair Aherrahrou3Zouhair Aherrahrou4Zouhair Aherrahrou5Jeanette Erdmann6Jeanette Erdmann7Jeanette Erdmann8Institute for Cardiogenetics, University of Lübeck, Lübeck, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, GermanyUniversity Heart Centre Lübeck, Lübeck, GermanyInstitute for Cardiogenetics, University of Lübeck, Lübeck, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, GermanyUniversity Heart Centre Lübeck, Lübeck, GermanyInstitute for Cardiogenetics, University of Lübeck, Lübeck, GermanyDZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, GermanyUniversity Heart Centre Lübeck, Lübeck, GermanyCardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of in vivo atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.https://www.frontiersin.org/article/10.3389/fcvm.2020.00109/fullatherosclerosisanimal modelsmousezebrafishimmune responsehuman disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Viviana L. Vedder Viviana L. Vedder Viviana L. Vedder Zouhair Aherrahrou Zouhair Aherrahrou Zouhair Aherrahrou Jeanette Erdmann Jeanette Erdmann Jeanette Erdmann
spellingShingle	Viviana L. Vedder Viviana L. Vedder Viviana L. Vedder Zouhair Aherrahrou Zouhair Aherrahrou Zouhair Aherrahrou Jeanette Erdmann Jeanette Erdmann Jeanette Erdmann Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish Frontiers in Cardiovascular Medicine atherosclerosis animal models mouse zebrafish immune response human disease
author_facet	Viviana L. Vedder Viviana L. Vedder Viviana L. Vedder Zouhair Aherrahrou Zouhair Aherrahrou Zouhair Aherrahrou Jeanette Erdmann Jeanette Erdmann Jeanette Erdmann
author_sort	Viviana L. Vedder
title	Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
title_short	Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
title_full	Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
title_fullStr	Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
title_full_unstemmed	Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
title_sort	dare to compare. development of atherosclerotic lesions in human, mouse, and zebrafish
publisher	Frontiers Media S.A.
series	Frontiers in Cardiovascular Medicine
issn	2297-055X
publishDate	2020-06-01
description	Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of in vivo atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.
topic	atherosclerosis animal models mouse zebrafish immune response human disease
url	https://www.frontiersin.org/article/10.3389/fcvm.2020.00109/full
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Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

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