Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy

Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy

Abstract Multiple system atrophy (MSA) is a rare, but fatal atypical parkinsonian disorder. The prototypical pathological hallmark are oligodendroglial cytoplasmic inclusions (GCIs) containing alpha-synuclein (α-syn). Currently, two MSA phenotypes are classified: the parkinsonian (MSA-P) and the cer...

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Bibliographic Details
Main Authors: Lisa Mészáros, Markus J. Riemenschneider, Heiko Gassner, Franz Marxreiter, Stephan von Hörsten, Alana Hoffmann, Jürgen Winkler
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple system atrophy
Cerebellar pathology
Cerebellar ataxia
Gait analysis
Online Access:https://doi.org/10.1186/s40478-021-01166-x

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