Performance of objective functions and optimisation procedures for parameter estimation in system biology models
Systems biology: Performance of parameter estimation procedures A systematic comparison of critical choices for faithful parameter-estimation identifies a combination of a hybrid optimisation algorithm (GLSDC) with data-driven normalisation of simulations (DNS) as the generally best option. Experime...
Main Authors: | Andrea Degasperi, Dirk Fey, Boris N. Kholodenko |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-08-01
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Series: | npj Systems Biology and Applications |
Online Access: | https://doi.org/10.1038/s41540-017-0023-2 |
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