Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures.

Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures.

Leber Hereditary Optic Neuropathy (LHON) is a maternally inherited form of visual loss, due to selective degeneration of retinal ganglion cells. Despite the established aetiological association between LHON and mitochondrial DNA mutations affecting complex I of the electron transport chain, the path...

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Bibliographic Details
Main Authors: Simone Beretta, John P.M. Wood, Barry Derham, Gessica Sala, Lucio Tremolizzo, Carlo Ferrarese, Neville N. Osborne
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Complex I
Leber hereditary optic neuropathy (LHON)
Reactive oxygen species
Excitotoxicity
GLAST
Retina
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001677

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