Experimental Validation on Tissue-Mimicking Phantoms of Millimeter-Wave Imaging for Breast Cancer Detection

• Main Authors: Simona Di Meo, Giulia Matrone, Marco Pasian
• Format: Article
• Language: English
• Published: MDPI AG 2021-01-01
• Series: Applied Sciences
• Subjects: breast cancer detection; early diagnosis; microwave imaging; millimeter-wave imaging; tissue-mimicking phantoms
• Online Access: https://www.mdpi.com/2076-3417/11/1/432

Breast cancer is one of the leading causes of cancer death among women; to decrease the death rate for this disease, early detection plays a key role. Recently, microwave imaging systems have been proposed as an alternative to the current techniques, but they suffer from poor resolution due to the low frequencies involved. In this paper, for the first time, an innovative millimeter-wave imaging system for early-stage breast cancer detection is proposed and experimentally verified on different breast phantoms. This has the potential to achieve superior resolution for breasts with a high volumetric percentage of adipose tissue, and the merit to overcome the common misconception that millimeter-waves cannot achieve useful penetration depths for biological applications. Three phantoms were prepared according to the dielectric properties of human breast <i>ex vivo</i> tissues in the frequency range [0.5–50] GHz. Two cylindrical inclusions made by water and gelatin or agar, mimicking dielectric properties of neoplastic tissues, were embedded in the phantom at different depths up to 3 cm. Two double ridge waveguides, with mono-modal frequency band equal to [¹⁸,¹⁹,²⁰,²¹,²²,²³,²⁴,²⁵,²⁶,²⁷,²⁸,²⁹,³⁰,³¹,³²,³³,³⁴,³⁵,³⁶,³⁷,³⁸,³⁹,⁴⁰] GHz, were used to synthetize a linear array of 24 elements in 28 positions, acquiring signals with a Vector Network Analyzer. The images were reconstructed by applying the Delay and Sum algorithm to calibrated data. The feasibility of a new imaging system with a central working frequency of about 30 GHz is experimentally demonstrated for the first time, and a target detection capability up to 3 cm within the phantom is shown. The presented results pave the way for a possible use of millimeter-waves to image non-superficial neoplasms in the breast.