Role of Electrostatic Interactions in Calcitonin Prefibrillar Oligomer-Induced Amyloid Neurotoxicity and Protective Effect of Neuraminidase

Role of Electrostatic Interactions in Calcitonin Prefibrillar Oligomer-Induced Amyloid Neurotoxicity and Protective Effect of Neuraminidase

Salmon calcitonin is a good model for studying amyloid behavior and neurotoxicity. Its slow aggregation rate allows the purification of low molecular weight prefibrillar oligomers, which are the most toxic species. It has been proposed that these species may cause amyloid pore formation in neuronal...

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Bibliographic Details
Main Authors: Ida Cariati, Roberto Bonanni, Mario Marini, Anna Maria Rinaldi, Beatrice Zarrilli, Virginia Tancredi, Claudio Frank, Giovanna D’Arcangelo, Marco Diociaiuti
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid neurotoxicity
salmon calcitonin
soluble prefibrillar oligomers
lipid rafts
GM1
neuraminidase
Online Access:https://www.mdpi.com/1422-0067/22/8/3947

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