Syntheses of two deacetyl-thymosin β4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw

• Main Authors: T. Abiko, R. Ogawa
• Format: Article
• Language: English
• Published: Hindawi Limited 2001-01-01
• Series: Mediators of Inflammation
• Online Access: http://dx.doi.org/10.1080/09629350120054563

Two {Met(0)6}deacetyl-thymosin β4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)6}deacetyl-thymosin β4, but the other analog, {Met(0)6, Tyr(Me)12}deacetyl-thymosin β4, showed a marked reduction of the anti-inflammatory effect.