Syntheses of two deacetyl-thymosin β4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw
Two {Met(0)6}deacetyl-thymosin β4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked anti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2001-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350120054563 |
| Summary: | Two {Met(0)6}deacetyl-thymosin β4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)6}deacetyl-thymosin β4, but the other analog,
{Met(0)6, Tyr(Me)12}deacetyl-thymosin β4, showed
a marked reduction of the anti-inflammatory effect. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |