Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

Disorders of the transparent cornea affect millions of people worldwide. However, how to maintain and/or regenerate this organ remains unclear. Here, we show that Rela (encoding a canonical NF-κB subunit) ablation in K14+ corneal epithelial stem cells not only disrupts corneal regeneration but also...

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Bibliographic Details
Main Authors: Qian Yu, Soma Biswas, Gang Ma, Peiquan Zhao, Baojie Li, Jing Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
angiogenesis inhibitor
blindness
corneal disorders
NF-κB
retinoic acid
Online Access:https://elifesciences.org/articles/67315

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