Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

Here and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on...

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Bibliographic Details
Main Authors: Marisol Gouveia, João Figueira, Manuel G. Jardim, Rita Castro, Helena Tomás, Kari Rissanen, João Rodrigues
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
dendrimers
nanocarriers
metallodrugs
ruthenium
platinum
cisplatin
cancer treatment
hMSCs
toxicity
nanomedicine
Online Access:http://www.mdpi.com/1420-3049/23/6/1471

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