Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of <i>N</i>-acetyl-cysteine and β-mercaptoethylamine

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of <i>N</i>-acetyl-cysteine and β-mercaptoethylamine

Glutathione (GSH) has poor pharmacokinetic properties; thus, several derivatives and biosynthetic precursors have been proposed as GSH-boosting drugs. I-152 is a conjugate of <i>N</i>-acetyl-cysteine (NAC) and <i>S</i>-acetyl-&#946;-mercaptoethylamine (SMEA) designed to r...

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Bibliographic Details
Main Authors: Rita Crinelli, Carolina Zara, Michaël Smietana, Michele Retini, Mauro Magnani, Alessandra Fraternale
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Nutrients
Subjects:
glutathione
pro-glutathione molecules
co-drug
antiviral activity
immunomodulation
<i>N</i>-acetyl-cysteine
cysteamine
Online Access:https://www.mdpi.com/2072-6643/11/6/1291

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https://www.mdpi.com/2072-6643/11/6/1291

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