Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii

Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii

Erik PH de Leeuw Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA Objective: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. Methods: Susceptibility to small molecule Lipid II inhibitor BAS00127538 w...

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Main Author: de Leeuw EPH
Format: Article
Language:English
Published: Dove Medical Press 2014-08-01
Series:Drug Design, Development and Therapy
Online Access:http://www.dovepress.com/efficacy-of-the-small-molecule-inhibitor-of-lipid-ii-bas00127538-again-peer-reviewed-article-DDDT
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spelling doaj-f36c2a10dc6448428cd84f309055ecec2020-11-25T00:30:07ZengDove Medical PressDrug Design, Development and Therapy1177-88812014-08-012014default1061106417880Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumanniide Leeuw EPH Erik PH de Leeuw Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA Objective: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. Methods: Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed. Results: Small molecule Lipid II inhibitor BAS00127538 potently acts against A. baumannii and acts synergistically with colistin. Conclusion: For the first time, a compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii. The synergy with colistin warrants further lead development of BAS00127538. Keywords: Lipid II, Acinetobacter baumannii, drug developmenthttp://www.dovepress.com/efficacy-of-the-small-molecule-inhibitor-of-lipid-ii-bas00127538-again-peer-reviewed-article-DDDT
collection DOAJ
language English
format Article
sources DOAJ
author de Leeuw EPH
spellingShingle de Leeuw EPH
Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
Drug Design, Development and Therapy
author_facet de Leeuw EPH
author_sort de Leeuw EPH
title Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_short Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_full Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_fullStr Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_full_unstemmed Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_sort efficacy of the small molecule inhibitor of lipid ii bas00127538 against acinetobacter baumannii
publisher Dove Medical Press
series Drug Design, Development and Therapy
issn 1177-8881
publishDate 2014-08-01
description Erik PH de Leeuw Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA Objective: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. Methods: Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed. Results: Small molecule Lipid II inhibitor BAS00127538 potently acts against A. baumannii and acts synergistically with colistin. Conclusion: For the first time, a compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii. The synergy with colistin warrants further lead development of BAS00127538. Keywords: Lipid II, Acinetobacter baumannii, drug development
url http://www.dovepress.com/efficacy-of-the-small-molecule-inhibitor-of-lipid-ii-bas00127538-again-peer-reviewed-article-DDDT
work_keys_str_mv AT deleeuweph efficacyofthesmallmoleculeinhibitoroflipidiibas00127538againstacinetobacterbaumannii
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