Aryl radical-mediated N-heterocyclic carbene catalysis

Aryl radical-mediated N-heterocyclic carbene catalysis

Use of aryl halides as coupling precursors typically occurs through transition metal catalysis and/or photoredox chemistry, which requires some combination of light, metals, and oxidants or reductants. Here, the authors show a method to generate aryl radicals from halides using only an NHC organocat...

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Main Authors: Yuki Matsuki, Nagisa Ohnishi, Yuki Kakeno, Shunsuke Takemoto, Takuya Ishii, Kazunori Nagao, Hirohisa Ohmiya
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24144-2
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spelling doaj-f36b6c5bc0004213ae418b24ec57fb2a2021-06-27T11:12:44ZengNature Publishing GroupNature Communications2041-17232021-06-011211810.1038/s41467-021-24144-2Aryl radical-mediated N-heterocyclic carbene catalysisYuki Matsuki0Nagisa Ohnishi1Yuki Kakeno2Shunsuke Takemoto3Takuya Ishii4Kazunori Nagao5Hirohisa Ohmiya6Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiDivision of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machiUse of aryl halides as coupling precursors typically occurs through transition metal catalysis and/or photoredox chemistry, which requires some combination of light, metals, and oxidants or reductants. Here, the authors show a method to generate aryl radicals from halides using only an NHC organocatalyst.https://doi.org/10.1038/s41467-021-24144-2
collection DOAJ
language English
format Article
sources DOAJ
author Yuki Matsuki
Nagisa Ohnishi
Yuki Kakeno
Shunsuke Takemoto
Takuya Ishii
Kazunori Nagao
Hirohisa Ohmiya
spellingShingle Yuki Matsuki
Nagisa Ohnishi
Yuki Kakeno
Shunsuke Takemoto
Takuya Ishii
Kazunori Nagao
Hirohisa Ohmiya
Aryl radical-mediated N-heterocyclic carbene catalysis
Nature Communications
author_facet Yuki Matsuki
Nagisa Ohnishi
Yuki Kakeno
Shunsuke Takemoto
Takuya Ishii
Kazunori Nagao
Hirohisa Ohmiya
author_sort Yuki Matsuki
title Aryl radical-mediated N-heterocyclic carbene catalysis
title_short Aryl radical-mediated N-heterocyclic carbene catalysis
title_full Aryl radical-mediated N-heterocyclic carbene catalysis
title_fullStr Aryl radical-mediated N-heterocyclic carbene catalysis
title_full_unstemmed Aryl radical-mediated N-heterocyclic carbene catalysis
title_sort aryl radical-mediated n-heterocyclic carbene catalysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Use of aryl halides as coupling precursors typically occurs through transition metal catalysis and/or photoredox chemistry, which requires some combination of light, metals, and oxidants or reductants. Here, the authors show a method to generate aryl radicals from halides using only an NHC organocatalyst.
url https://doi.org/10.1038/s41467-021-24144-2
work_keys_str_mv AT yukimatsuki arylradicalmediatednheterocycliccarbenecatalysis
AT nagisaohnishi arylradicalmediatednheterocycliccarbenecatalysis
AT yukikakeno arylradicalmediatednheterocycliccarbenecatalysis
AT shunsuketakemoto arylradicalmediatednheterocycliccarbenecatalysis
AT takuyaishii arylradicalmediatednheterocycliccarbenecatalysis
AT kazunorinagao arylradicalmediatednheterocycliccarbenecatalysis
AT hirohisaohmiya arylradicalmediatednheterocycliccarbenecatalysis
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