Effects of Imatinib on Rat Liver
Aim:Imatinib is a protein tyrosine kinase inhibitor that’s used as an anticancer drug. In this study, evaluation the effects of different doses of imatinib on liver ultrastructurally and biochemically was aimed.Methods:200-250 g, 8-12 weeks old, 30 mature male Wistar rats were used. Rats were divide...
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-01-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/effects-of-matinib-on-rat-liver/43959
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| Summary: | Aim:Imatinib is a protein tyrosine kinase inhibitor that’s used as an anticancer drug. In this study, evaluation the effects of different doses of imatinib on liver ultrastructurally and biochemically was aimed.Methods:200-250 g, 8-12 weeks old, 30 mature male Wistar rats were used. Rats were divided in 5 groups; 10, 50, 100 and 200 mg/kg imatinib daily were administered by gavage during 21 days to the experimental groups respectively. Fifth group was control; saline was given. Serum levels of liver transaminases, bilirubin, alkaline phosphatase were examined, morphological effects were investigated via electron microscopy.Results:In 10 mg/kg and 50 mg/kg imatinib applied experimental groups, the nuclear and cytoplasmic structures, sinusoidal and perisinusoidal areas were similar to the control group. In 100 mg/kg imatinib applied group cytoplasmic density was increased, lytic areas and lipid accumulation in cytoplasm of some hepatocytes were seen. In 200 mg/kg imatinib applied experimental group lytic changes and lipid accumulation were prominent.Conclusion:It is concluded that, protein-tyrosine kinase inhibitor imatinib may cause dose related degenerative changes in the liver, and liver functions should be monitored in patients during treatment. |
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| ISSN: | 2147-2688 2147-2688 |