Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Being able to predict the therapeutic benefit of disease modifying anti-rheumatic drugs (DMARDs) would be of great benefit and a stepping stone towards personalized medicine. Here the authors use machine learning and lipid mediator mass spectrometry to show specialized pro-resolving mediators are in...

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Main Authors:	Esteban A. Gomez, Romain A. Colas, Patricia R. Souza, Rebecca Hands, Myles J. Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19176-z

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spelling	doaj-f34fbd1c4b4842aeb4be2cce58f65db22021-05-11T08:23:28ZengNature Publishing GroupNature Communications2041-17232020-10-0111111310.1038/s41467-020-19176-zBlood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritisEsteban A. Gomez0Romain A. Colas1Patricia R. Souza2Rebecca Hands3Myles J. Lewis4Conrad Bessant5Costantino Pitzalis6Jesmond Dalli7William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonSchool of Biological and Chemical Sciences, Queen Mary University of LondonCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonBeing able to predict the therapeutic benefit of disease modifying anti-rheumatic drugs (DMARDs) would be of great benefit and a stepping stone towards personalized medicine. Here the authors use machine learning and lipid mediator mass spectrometry to show specialized pro-resolving mediators are indicative of DMARD responsiveness among rheumatoid arthritis patients.https://doi.org/10.1038/s41467-020-19176-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Esteban A. Gomez Romain A. Colas Patricia R. Souza Rebecca Hands Myles J. Lewis Conrad Bessant Costantino Pitzalis Jesmond Dalli
spellingShingle	Esteban A. Gomez Romain A. Colas Patricia R. Souza Rebecca Hands Myles J. Lewis Conrad Bessant Costantino Pitzalis Jesmond Dalli Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis Nature Communications
author_facet	Esteban A. Gomez Romain A. Colas Patricia R. Souza Rebecca Hands Myles J. Lewis Conrad Bessant Costantino Pitzalis Jesmond Dalli
author_sort	Esteban A. Gomez
title	Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
title_short	Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
title_full	Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
title_fullStr	Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
title_full_unstemmed	Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis
title_sort	blood pro-resolving mediators are linked with synovial pathology and are predictive of dmard responsiveness in rheumatoid arthritis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Being able to predict the therapeutic benefit of disease modifying anti-rheumatic drugs (DMARDs) would be of great benefit and a stepping stone towards personalized medicine. Here the authors use machine learning and lipid mediator mass spectrometry to show specialized pro-resolving mediators are indicative of DMARD responsiveness among rheumatoid arthritis patients.
url	https://doi.org/10.1038/s41467-020-19176-z
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Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

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