The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies

The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies

Coumarins are plant-derived secondary metabolites. The crystal structure of three coumarins—bergamottin, osthole and fraxidin—are described and we analyze intermolecular interactions and their role in crystal formation. Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibi...

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Bibliographic Details
Main Authors: Miriam Rossi, Sandjida Aktar, Marissa Davis, Emily Hefter Feuss, Samara Roman-Holba, Kelly Wen, Christopher Gahn, Francesco Caruso
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
coumarin
grapefruit effect
bergamottin
fraxidin
osthole
CYP3A4
Online Access:https://www.mdpi.com/1420-3049/25/14/3158

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